Proteome Exploration Laboratory

Shu-ou Shan – Principal Investigator
Tsui-Fen Chou РInterim Director

The Proteome Exploration Laboratory provides both scientific and technical expertise and state-of-the-art high performance and ultrahigh performance liquid chromatography and tandem mass spectrometric instrumentation.

The lab is currently equipped with an Agilent 1100 MSD instrument, two Thermo EASY-nLC Orbitrap instruments (Classic and Elite), and an Thermo EASY-nLC LTQFT linear ion trap with electron capture dissociation (ECD) and infrared multiple photon dissociation (IRMPD) capabilities and an AB Sciex nanoLC QTRAP. Ancillary instrumentation includes a Nanomate direct infusion device, additional HPLC systems, capillary puller etc. Our bioinformatics suite contains a Mascot server, MaxQuant, the TransProteomics Pipeline, Scaffold, Sequest, ROCCIT and other in-house developed software tools that are constantly being developed.

A major research focus within the laboratory is method development for comparative quantitative proteome analysis, including the comprehensive analysis of posttranslational modifications.

We collaborate with California Institute of Technology scientists from various backgrounds. By nature, the level of collaboration varies from project to project. To achieve best results, we encourage investigators to contact us before a project is started.

People

Prof. Tsui-Fen Chou

Interim Director

  • 314C – Broad Center for Biological Science
  • Mail Code 114-96
  • tfchou@caltech.edu

Prof. Shu-ou Shan

Principal Investigator

  • 109 – Braun Lab
  • Mail Code 147-75
  • sshan@caltech.edu

Dr. Jeff Jones

Senior Bioinformatician

  • 201 – Beckman Institute
  • Mail Code 139-74
  • jeffj@caltech.edu

Dr. Brett Lomenick

Staff Scientist

  • 201 – Beckman Institute
  • Mail Code 139-74
  • lomenick@caltech.edu

Dr. Shekufeh Zareian

Research Associate

  • 201 – Beckman Institute
  • Mail Code 139-74
  • szareian@caltech.edu